Synthesis of New Coumarin-C<sub>3</sub> Benzimidazole Hybrids and Their Urease Inhibition Studies

Akyüz G., Mentese E.

LETTERS IN ORGANIC CHEMISTRY, cilt.20, sa.9, ss.864-870, 2023 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 20 Sayı: 9
  • Basım Tarihi: 2023
  • Doi Numarası: 10.2174/1570178620666230418113901
  • Dergi Adı: LETTERS IN ORGANIC CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Chemical Abstracts Core
  • Sayfa Sayıları: ss.864-870
  • Anahtar Kelimeler: Hybridization, coumarin-benzimidazole hybrids, chlorine atom, urease activity, weatherburn's method, fused hybrids
  • Recep Tayyip Erdoğan Üniversitesi Adresli: Evet

Özet

A novel series of coumarin-benzimidazole hybrids were designed, synthesized, and extensively characterized using spectral data, including FT-IR, 1H-NMR, and 13C-NMR. Weatherburn's method was used to test new compounds' inhibition of urease activity. The results were evaluated by considering the effects of different side groups and hybridization. The chlorine atom in the molecules notably affects the inhibitory activity of urease. The best result was obtained with the compound “6- chloro-N'-{[5,6-dichloro-2-(2-thienylmethyl)-1H-benzimidazol-1-yl]acetyl}-2-oxo-2H-chromene-3- carbohydrazide” (3b) with IC50= 12.48±0.12 μg/mL against Jack bean urease.