SYNTHESIS AND STUDY OF ANTITUMOR ACTIVITY OF SOME NEW 2-(4-METHOXYBENZYL)-1H-BENZIMIDAZOLE DERIVATIVES BEARING TRIAZOLE, OXADIAZOLE AND ETHANOL MOIETY

Karaali N., Mentese E.

REVUE ROUMAINE DE CHIMIE, cilt.61, sa.3, ss.187-192, 2016 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 61 Sayı: 3
  • Basım Tarihi: 2016
  • Dergi Adı: REVUE ROUMAINE DE CHIMIE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.187-192
  • Anahtar Kelimeler: benzimidazole, carbothioamide, 1,2,4-triazole, 1,3,4-oxadiazole, antitumor activity, BENZIMIDAZOLE DERIVATIVES, BIOLOGICAL EVALUATION, 1,3,4-THIADIAZOLES, 1,3,4-OXADIAZOLES
  • Recep Tayyip Erdoğan Üniversitesi Adresli: Evet

Özet

A series of novel 1,2-disubstituted benzimidazole derivatives containing hydrazinecarbothioamide (7a-c), 1,2,4-triazole (8a-c) and 1,3,4-oxadiazole (5) moiety were synthesized starting from 2-(4-methoxybenzyl)-1H-benzimidazole. Then, the compounds 8a-c, 5 were converted to allcylated analogs (9a-c, 6) in the presence of K2CO3 and 2-bromoethanol. The structures of all the synthesized compounds were elucidated by H-1, C-13 NMR and mass spectroscopy. The newly synthesized compounds were tested on the five human cancer cells (breast (BT-20), melanoma (SK-Mel 128), prostate (DU-145), liver (SNU-398) andlung (A549)). The compound 7a had some degree of cytotoxicity against BT-20.