Atıf İçin Kopyala
Cure E., Kirbas A., TÜMKAYA L., Cure M. C., Kalkan Y., YILMAZ A., ...Daha Fazla
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS, cilt.11, sa.1, ss.164-169, 2015 (SCI-Expanded)
-
Yayın Türü:
Makale / Tam Makale
-
Cilt numarası:
11
Sayı:
1
-
Basım Tarihi:
2015
-
Doi Numarası:
10.4103/0973-1482.140809
-
Dergi Adı:
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
-
Derginin Tarandığı İndeksler:
Science Citation Index Expanded (SCI-EXPANDED), Scopus
-
Sayfa Sayıları:
ss.164-169
-
Anahtar Kelimeler:
Arginase, carbamoyl phosphate synthetase 1, hepatotoxicity, infliximab, methotrexate, TUMOR-NECROSIS-FACTOR, NITRIC-OXIDE, CELL-GROWTH, INDUCED HEPATOTOXICITY, APOPTOSIS, THERAPY, CANCER
-
Recep Tayyip Erdoğan Üniversitesi Adresli:
Evet
Özet
Aims: Although methotrexate (mtx) is a widely used agent to treat cancer and inflammatory diseases, its hepatotoxic effect limits for clinical utility. We aimed to investigate whether infliximab (inf), an inhibitor of tumor necrosis factor-alpha (TNF-alpha) has a protective effect against mtx-induced hepatotoxicity.