Infliximab Modulates Cisplatin-Induced Hepatotoxicity in Rats

Cure M. C., Cure E., Kalkan Y., Kirbas A., Tumkaya L., Yilmaz A., ...Daha Fazla

BALKAN MEDICAL JOURNAL, cilt.33, sa.5, ss.504-511, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Sayı: 5
  • Basım Tarihi: 2016
  • Doi Numarası: 10.5152/balkanmedj.2016.150576
  • Dergi Adı: BALKAN MEDICAL JOURNAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.504-511
  • Anahtar Kelimeler: Carbamoyl-phosphate synthetase 1, carbonic anhydrase, cisplatin, hepatotoxicity, infliximab, tumor necrosis factor alpha, CARBONIC-ANHYDRASE II, INDUCED LIVER-INJURY, OXIDATIVE STRESS, TOPIRAMATE, CANCER, IX
  • Recep Tayyip Erdoğan Üniversitesi Adresli: Evet

Özet

Background: Cisplatin (Cis) is one of the most commonly used antineoplastic drugs. It is used as chemotherapy for many solid organ malignancies such as brain, neck, male and female urogenital, vesical and pulmonary cancers. Infliximab blocks tumor necrosis factor alpha (TNF-alpha). Several studies have reported that infliximab ameliorates cell damage by reducing cytokine levels.