Synthesis and spectroscopic characterization of novel methoxy bridged benzimidazolyl-substituted phthalocyanines as potent inhibitors of urease

Akcay H. T., Mentese E., Sokmen B. B.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, cilt.228, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 228
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1016/j.saa.2019.117804
  • Dergi Adı: SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Chimica, Compendex, EMBASE, INSPEC, MEDLINE, Veterinary Science Database
  • Anahtar Kelimeler: Phthalocyanine, Electronic absorption, Aggregation, Urease inhibition activity, METAL-FREE, SPECTROELECTROCHEMICAL PROPERTIES, ELECTROCHEMICAL PROPERTIES, PHOTOCHEMICAL PROPERTIES, FLUORESCENCE PROPERTIES, CATALYTIC-ACTIVITY, ZINC(II), METALLOPHTHALOCYANINES
  • Recep Tayyip Erdoğan Üniversitesi Adresli: Evet

Özet

In this study, novel peripherally 4-[(1H-benzimidazol-1-yl)methoxy] substituted Zn(II) (3) Cu(II) (4) and Co(II) (5) phthalocyanines were prepared and their structures were characterized spectroscopically. The light absorption behaviors of the synthesized compounds (3-5) were studied by UV-Vis spectroscopy at different concentrations in different solvents. The urease inhibition activities of the synthesized compounds were also investigated. Among the synthesized molecules, compound 4 showed the best inhibitory effect against jack bean urease with IC50 values of 0.0036 +/- 0.0010 mu M. (C) 2019 Elsevier B.V. All rights reserved.