Urease and acetylcholinesterase enzyme inhibitor novel phthalonitrile azo compounds

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KANTAR C., BALTAŞ N., Dereci O. K., ŞAŞMAZ S.

INDIAN JOURNAL OF CHEMISTRY, cilt.61, sa.11, ss.1188-1193, 2022 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 61 Sayı: 11
  • Basım Tarihi: 2022
  • Doi Numarası: 10.56042/ijc.v61i11.68270
  • Dergi Adı: INDIAN JOURNAL OF CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core
  • Sayfa Sayıları: ss.1188-1193
  • Anahtar Kelimeler: Phthalonitrile, Azo dyes, Urease, Acetylcholinesterase, Enzyme inhibition, MICROWAVE-ASSISTED SYNTHESIS, HELICOBACTER-PYLORI INFECTION, PHTHALOCYANINES, EUGENOL, AMINOPYRIDINES, DISEASE
  • Recep Tayyip Erdoğan Üniversitesi Adresli: Evet

Özet

Based on the relationship between Helicobacter pylori and Alzehimer's disease, new azo phthalonitrile compounds containing different amino pyridines have been synthesized. These compounds can inhibit both Urease and Acetylcholinesterase, which are the most important enzymes in the treatment of Helicobacter pylori and Alzehimer's disease, respectively. All compounds have shown better inhibition than standards in the presence of both enzymes. Especialy, azo phthalonitrile compound 4 is more active than other compounds and standards, showed a significant inhibition performance and efficient IC50 values to Urease (20.47 +/- 0.14 mu M) and Acetylcholinesterase (4.73 +/- 0.07 mu M) enzymes. Interestingly, the inhibitory effect of the newly synthesized compounds against to Urease and Acetylcholinesterase is same ranking.