An efficient microwave-assisted synthesis of novel quinolone-triazole and conazole-triazole hybrid derivatives as antimicrobial and anticancer agents

Cebeci Y. U., CEYLAN Ş., ALPAY KARAOĞLU Ş., ALTUN M.

JOURNAL OF HETEROCYCLIC CHEMISTRY, cilt.60, sa.1, ss.47-62, 2023 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 60 Sayı: 1
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1002/jhet.4560
  • Dergi Adı: JOURNAL OF HETEROCYCLIC CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aquatic Science & Fisheries Abstracts (ASFA), Chemical Abstracts Core, Chimica, EMBASE
  • Sayfa Sayıları: ss.47-62
  • Recep Tayyip Erdoğan Üniversitesi Adresli: Evet

Özet

1,2,4-Triazole-fluoroquinolone and 1,2,4-triazole-conazole hybrids are designed, synthesized, and investigated in vitro against a variety of common diseases. The structure of the newly synthesized compounds are characterized from spectral data (IR, H-1 NMR, C-13 NMR, and LC-MS). The antibacterial activity against both Gram-positive and Gram-negative bacteria is shown to be enhanced by many of the produced compounds. Also, some of the products are found to have strong antiproliferative effects aganist HeLa cervical cancer cells, whilst demonstrating cytotoxic effects toward normal cells.